Journal of Dental Medicine

Background and Aims: Non-steroidal anti-inflammatory drugs (NSAIDs) are the most common drugs prescribed for controlling and post root canal treatment pain. During the last decade, a new generation of NSAIDs has been introduced such as Celecoxib and Gelofen with less gastrointestinal side effects and more analgesic effect. No studies have been performed to compare Celecoxib and Gelofen with other NSAIDs considering the reduction of post-endodontic pain therefore, this study was designed.
Materials and Methods: In this randomized double blind clinical trial study, 90 patients were divided into 3 groups and underwent root canal therapy. Celecoxib, Gelofen, or placebo was randomized prescribed to the patients 1 hour before treatment. The intensity of pain was recorded using visual analog scale (VAS) at 4, 8, 12, 24, 48 hours after completion of root canal treatment. The data were analyzed by means of repeated measurements, multiple comparisons and one-way ANOVA tests using SPSS software. P<0.05 was considered as the level of significance.
Results: The results showed significant difference between Celecoxib and Gelofen in comparison with placebo at 8 and 12 hours after initiation of treatment. There was no significant difference among three groups at 4, 24, and 48 hours after initiation of treatment.
Conclusion: According to the results, use of Gelofen or Celecoxib before treatment reduces post-endodontic pain. These drugs can be prescribed before initiation of treatment as the effective agents for reduction of post-endodontic pain

  Background and Aims : Antibiotics are commonly used for controlling the growth of porphyromons gingivalis (P.g) which is one of the most important etiologic factors in the periodontal diseases. Different side effects of synthetics and chemical drugs such as increasing the drug resistancy in the human pathogens have led to study on the herbal antibacterial effect. The aim of this study was to evaluate the antibacterial effect of cinnamon on the growth of porphyromons gingivalis in chronic periodontitis patients with deep pockets.

  Materials and Methods: In this experimental study, samples were provided from patients having pockets. After culturing the microorganism and diagnosis of P.g by gram staining and biochemical tests, cinnamon in different concentrations (10, 50, 100, 250, 500, 750 and 1500 mg/ml ) with oil solvent were prepared and placed by disks in the cultures medium. Positive controls were amoxicillin, metronidazole, ciprofloxacin, amikacin and gentamycin . Oil was negative control. Then the plates were incubated for 24 hours in 37 ⁰ C and then non-growth halos by disk diffusion method, MIC (Minimum Inhibitory Concentration) and MBC (Minimum Bactericidal Concentration) were determined. Data were analyzed using One-way ANOVA test.

  Results: The results showed that the cinnamon at the concentration of MIC=750 mg/ml had the inhibitory effects of bacteria and at the concentration of MIC=1500 mg/ml had killing effect. However, this antibacterial effect compared with commonly used antibiotics (amoxicillin, metronidazole), was much weaker (P<0.001).

  Conclusion: Cinnamon showed an antimicrobial effect on porphyromonas gingivalis in chronic periodontitis patients with deep pockets.

  Background and Aims: The ability of composite restorations to prevent microleakage needs desirable bonding material for proper sealing . The purpose of this study was to evaluate class V composite restorations microleakage in premolars with/without electric current while applying variant dentin bonding in vitro.

  Materials and Methods: 120 non-carious human premolars were used for this study and standardized class v cavities were prepared. The tooth roots were cut by discs at a distance of 5 mm from CEJ and pulp tissue was removed. The teeth were divided into six groups of 20. In the first group, electric current was applied, Single bond (3M ESPE, St Paul, MN, USA) with a broom motion attached to the cathode and a sponge containing bonding was used as anode. The used current was 15µA and the Single bond in the second group was used without electricity. Then two bondings PQ1 (Ultradent, Germany) and Optibond solo plus (Kerr, USA) were used with and without electricity. After adhesive application and curing the bonding agents, cavities were restored by a composite (Valux Plus). The root ends were sealed by wax and all teeth surfaces, except 1 mm around the restorations were covered with a nail varnish. The specimens were thermocycled for 1000 cycles and placed in fushin for 24 hours and were then sectioned vertically and examined under a stereomicroscope. Data were scored on a 0-4 scale based on microleakage at the gingival margins and analyzed using Kruskal-Wallis and Mann-whitney test.

  Results: Based on the results, the extent of microleakage in the groups of electric current was significantly less than the groups without using the electric current (P=0.05). The lowest degree of microleakage was found in PQ1 group, and the greatest difference between the groups with and without electricity was also found in PQ1 group. Single bond and Optibond Solo Plus with electric current showed a lower degree of microleakge.

  Conclusion: The result showed that use of electric current during the application of dental adhesives could reduce the extent of microleakage.